BODY INTEGRITY IDENTITY DISORDER REGISTRATION

BODY INTEGRITY IDENTITY DISORDER REGISTRATION

I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as. The study was carried out according to the Helsinki declaration guidelines.Īll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Informed consent was provided by participants prior to participation in the study, which had been approved by the Ethics Committee of the University Hospital of Zurich and by the Ethical Committee Milano Area C.

The details of the IRB/oversight body that provided approval or exemption for the research described are given below: I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. All authors revised and the manuscript and approved the final version. Pbru, Gbot, Gsae, Mgan, Blen performed the clinical interview. Gsae, Mgan, Lzap, Gsal, Msbe collected the neuroimaging data. BLen, Pbru, Gbot conceptualized the project. The authors have declared no competing interest. These findings consolidate current understanding of the neural correlates of BID, which might in turn guide diagnostics and rehabilitative treatments. Alongside this network for bodily awareness, other networks such as the limbic (rMFGOrb) and the mirror (lMTG) systems showed structural alterations as well. By using a complementary method of investigation, we confirmed and extended previous results showing alterations in areas tuned to the processing of the sensorimotor representations of the affected leg (rPCL), and to higher-order components of bodily representation such as the body image (rSPL). Increased connectivity was observed between the right paracentral lobule (rPLC) and the right caudate nucleus. Results showed reduced structural connectivity of: i) the right superior parietal lobule (rSPL) with the right cuneus, superior occipital and posterior cingulate gyri ii) the pars orbitalis of the right middle frontal gyrus (rMFGOrb) with the putamen iii) the left middle temporal gyrus (lMTG) with the pars triangularis of the left inferior frontal gyrus. Fractional anisotropy (FA), derived from Diffusion Tensor Imaging data, was considered as a measure of structural connectivity. Here we aimed to identify in the same sample altered patterns of white matter structural connectivity.

We previously demonstrated altered brain structural (gray matter) and functional connectivity in 16 men with a long-lasting and exclusive desire for left leg amputation. Limb amputation is desired for restoring their own identity. “Body integrity dysphoria” (BID) is a severe condition affecting non-psychotic individuals where a limb may be experienced as not being part of the body, despite normal anatomical development and intact sensorimotor functions.

Body integrity identity disorder